It’s still a work in progress, but I’ve found a way to register a click even on any element with css3 and html5. It makes use of the contenteditable html5 attribute and :focus css pseudo-class. It’s current bugs include difficulty closing the lightbox and one time a webkit browser crashed, but I think that was caused by something else.
Demo

Zuko
On the right is an example, but be careful, it did crash espresso once, don’t use it if you have unsaved work open in the browser!
It would be nice to reduce the photo by clicking on the photo , not only by clicking on the body